Effect of dietary fructose on portal and systemic serum fructose levels in rats and in KHK
نویسندگان
چکیده
Chirag Patel,* Keiichiro Sugimoto,* Veronique Douard, Ami Shah, Hiroshi Inui, Toshikazu Yamanouchi, and Ronaldo P. Ferraris Department of Pharmacology and Physiology, New Jersey Medical School, Rutgers University, Newark, New Jersey; Research and Development Center, Nagaoka Perfumery Co., Ltd., Ibaraki, Osaka, Japan; Center for Research and Development of Bioresources, Osaka Prefecture University, Sakai, Osaka, Japan; Department of Clinical Nutrition, College of Health and Human Sciences, Osaka Prefecture University, Habikino, Osaka, Japan; and Department of Internal Medicine, Teikyo University, Tokyo, Japan
منابع مشابه
Effect of dietary fructose on portal and systemic serum fructose levels in rats and in KHK-/- and GLUT5-/- mice.
Elevated blood fructose concentrations constitute the basis for organ dysfunction in fructose-induced metabolic syndrome. We hypothesized that diet-induced changes in blood fructose concentrations are regulated by ketohexokinase (KHK) and the fructose transporter GLUT5. Portal and systemic fructose concentrations determined by HPLC in wild-type mice fed for 7 days 0% free fructose were <0.07 mM...
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تاریخ انتشار 2015